Publications
* Denotes corresponding authorship
2024
Sipko, E.L., Chappell, G.F., and Berlow, R.B*. 2024. Multivalency emerges as a common feature of intrinsically disordered protein interactions. Current Opinion in Structural Biology 84: 102742.(Link)
2023
Martinez-Yamout, M.A., Nasir, I., Shnitkind, S., Ellis, J.P., Berlow, R.B., Kroon, G., Deniz, A.A., Dyson, H.J., and Wright, P.E. 2023. Glutamine-rich Regions of the Disordered CREB Transactivation Domain Mediate Dynamic Intra- and Intermolecular Interactions. PNAS 120: e2313835120.(Link)
2022
Usui-Ouchi, A., Eade, K., Giles, S., Ideguchi, Y., Ouchi, Y., Aguilar, E., Wei, G., Marra, K.V., Berlow, R.B., and Friedlander, M. 2022. Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis. GLIA 70: 1762-1776. (Link)
Skeens, E., Gadzuk-Shea, M., Shah, D., Bhandari, V., Schweppe, D.K., Berlow, R.B.*, and Lisi, G.P.* 2022. Redox-Dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery. Structure 30: 840-850. (Link)
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2022. Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins. PNAS 119: e2117338119. (Link)
2021
Appling F.D., Berlow, R.B., Stanfield, R.L., Dyson, H.J., and Wright, P.E. 2021. The molecular basis of allostery in a facilitated dissociation process. Structure 29: 1327-1338. (Link)
Eade, K., Gantner, M.L., Hostyk, J.A., Nagasaki, T., Giles, S., Fallon, R., Harkins-Perry, S., Baldini, M., Lim, E.W., Scheppke, L., Dorrell, M.I., Cai, C., Baugh, E.H., Wolock, C.J., Wallace, M., Berlow, R.B., Goldstein, D.B., Metallo, C.M., Friedlander, M., and Allikmets, R. 2021. Serine biosynthesis defect due to haploinsufficiency of phosphoglycerate dehydrogenase (PHGDH) causes retinal disease. Nature Metabolism 3: 366-377. (Link)
2020
Usui-Ouchi, A., Aguilar, E., Murinello, S., Prins, M., Gantner, M.L., Wright, P.E., Berlow, R.B.* and Friedlander, M*. 2020. An allosteric peptide inhibitor of HIF-1a regulates hypoxia-induced retinal neovascularization. PNAS 117: 28297-28306. (Link)
2019
Berlow, R.B., Martinez-Yamout, M.A., Dyson, H.J., and Wright, P.E. 2019. Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein. Biochemistry 58: 1354-1362. (Link)
2018
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2018. Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation. Journal of Molecular Biology 430: 2309-2320. (Link)
Berlow, R.B.* 2018. A dual regulatory role for the disordered C-terminus of protein kinase Ca. Biophysical Journal 114: 1513-1514. (Link)
Berlow, R.B. and Wright, P.E. 2018. Tight complexes from disordered proteins. Nature 555: 37-38. (Link)
2017
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2017. Hypersensitive termination of the hypoxic response by a disordered protein switch. Nature 543: 447-451. (Link)
2015
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2015. Functional advantages of dynamic protein disorder. FEBS Letters 589: 2433-2440. (Link)
2012
Berlow, R.B., Swain, M., Dalal, S., Sweasy, J.B., and Loria, J.P. 2012. Substrate-Dependent Millisecond Domain Motions in DNA Polymerase β. Journal of Molecular Biology 419: 171-182. (Link)
2009
Wang, Y., Berlow, R.B., and Loria, J.P. 2009. Role of Loop-Loop Interactions in Coordinating Motions and Enzymatic Function in Triosephosphate Isomerase. Biochemistry 48: 4548-4556. (Link)
2008
Loria, J.P., Berlow, R.B., and Watt, E.D. 2008. Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion. Accounts of Chemical Research 41: 214-221. (Link)
2007
Berlow, R.B., Igumenova, T.I., and Loria, J.P. 2007. Value of a Hydrogen Bond in Triosephosphate Isomerase Loop Motion. Biochemistry 46: 6001-6010. (Link)
